The Titans established a franchise record with their 12th consecutive regular season victory, while capturing their sixth straight game on the road, also a franchise mark.
Collins threw for 289 yards, his highest total as a Titan, throwing touchdown passes to Bo Scaife (10 yards) and Justin Gage (12 yards). Chicago's defense bottled up Tennessee's running game, holding the Titans to just 20 yards on the ground. Chris Johnson, the AFC's leading rusher, totaled 8 yards on 14 attempts, while LenDale White managed 14 yards on 10 carries.
Bears rookie running back Matt Forte led Chicago with 72 yards on 20 attempts and seven catches for 54 yards. Brandon Jones caught a career-high 8 passes for 82 yards, while Bo Scaife set a career high with 10 receptions for 78 yards.
Bears QB Rex Grossman, filling in for injured starter Kyle Orton, completed 20-of-37 passes for 173 yards with one touchdown and an interception.
The Titans play at Jacksonville on Sunday.