The Bills visit Nissan Stadium (Oct. 18) for the third consecutive season and for the second consecutive year in primetime. The Titans defeated the Bills on a Tuesday night in 2020, following a two-day postponement due to a COVID-19 outbreak. In 2020, Titans quarterback Ryan Tannehill and Buffalo's Josh Allen became the fourth and fifth quarterbacks in NFL history with at least 3,800 passing yards, 33 passing touchdowns and seven rushing touchdowns in the same season. The Titans have won seven of their past nine Monday night games, including most recently their 2020 season opener at Denver.

Players and Coaches to Know

Buffalo Bills

Head Coach: Sean McDermott
Quarterback: Josh Allen
Key Players: WR Stefon Diggs, CB Tre'Davious White

Tennessee Titans

Head Coach: Mike Vrabel
Quarterback: Ryan Tannehill
Key Players: RB Derrick Henry, WR A.J. Brown