In a nationally-televised game on Thursday Night Football, San Francisco makes its third regular season appearance at Nissan Stadium (Dec. 23). San Francisco quarterback Trey Lance was the third-overall selection in the 2021 NFL Draft and is the former North Dakota State teammate of Titans second-round rookie tackle Dillon Radunz. It will mark the first Thursday night game for the Titans franchise against an NFC opponent (excluding Thanksgiving daytime kickoffs).

Players and Coaches to Know

San Francisco 49ers

Head Coach: Kyle Shanahan
Quarterback: Jimmy Garoppolo
Key Players: TE George Kittle, LB Fred Warner

Tennessee Titans

Head Coach: Mike Vrabel
Quarterback: Ryan Tannehill
Key Players: RB Derrick Henry, WR A.J. Brown