WEEK 16 · Sun 09/12 · 12:00 PM CDT
In a nationally-televised game on Thursday Night Football, San Francisco makes its third regular season appearance at Nissan Stadium (Dec. 23). San Francisco quarterback Trey Lance was the third-overall selection in the 2021 NFL Draft and is the former North Dakota State teammate of Titans second-round rookie tackle Dillon Radunz. It will mark the first Thursday night game for the Titans franchise against an NFC opponent (excluding Thanksgiving daytime kickoffs).
Players and Coaches to Know
San Francisco 49ers
Head Coach: Kyle Shanahan
Quarterback: Jimmy Garoppolo
Key Players: TE George Kittle, LB Fred Warner
Tennessee Titans
Head Coach: Mike Vrabel
Quarterback: Ryan Tannehill
Key Players: RB Derrick Henry, WR A.J. Brown
