NASHVILLE – On Homecoming Weekend, the Titans sent the Colts home with another loss.
This time, the Titans beat the Colts 19-10.
It was Tennessee's fifth straight win over Indianapolis, and their sixth win in the last seven games in the series.
The Titans have swept the Colts two years in a row.
"It feels really good," Titans safety Kevin Byard. "To sweep them two years in a row, obviously after their owner (Jim Irsay) makes all these statements about, 'We've got to beat the Titans' and stuff like that. It feels really good, and we're definitely going to celebrate this. As of right now, we don't have to worry about them. We've got a division game against Houston now we have to get on the road."
With the win, the Titans improved their record to 4-2, and the team remains in first place in the AFC South, where the Colts (3-3-1), Texans (1-3-1 heading into Sunday) and Jaguars (2-5) trail them.
After starting the season 0-2, the Titans have now won four games in a row.
"I'm extremely proud of these guys, proud of all three phases," Titans coach Mike Vrabel said. "Being able to get a victory, against an opponent that clearly shows they're not going to go away. But I am proud of our guys for finding ways to win, and hopefully we can continue as we work our way into Houston, in this division.
"It certainly feels good to be able to say that we've won four games in a row, and for the most part doing things the way that we think they should be done right now."
Titans running back Derrick Henry ran for 128 yards in the game, on 30 carries. It was Henry's third straight 100-yard game.
Quarterback Ryan Tannehill completed 13-of-20 passes for 132 yards. He was sacked twice on a day when the Titans managed 254 yards of offense, and 16 first downs.
Kicker Randy Bullock came up big with four field goals, from 27, 28, 38 and a big one from 48 yards out late.
But on this day, Titans fans owed a big thanks to a defense that flustered Colts quarterback Matt Ryan all game, sacking him three times and intercepting him twice, including one safety Andrew Adams returned for a touchdown.
"We've shown toughness all year," said Tannehill, who left the game briefly with an ankle injury, which had him in a walking boot post-game. "I'm proud of our guys the way we battled today. The defense played great all game, got some big stops for us. The offense did enough, and got the job done there at the end. We were able to move the ball and get points in crucial situations, and on the last drive there we were able to get a couple of first downs and run out the clock."
Early on, the Titans took a 3-0 lead on a 27-yard field goal by Bullock. It capped an 11-play, 62-yard drive that was highlighted by a 27-yard pass from Tannehill to receiver Cody Hollister and a 13-yard completion from Tannehill to receiver Robert Woods.
The Titans then got a big play on defense.
With the Colts driving, Adams stepped in from a pass thrown by Ryan and intercepted it before racing 76 yards for a touchdown, which gave the Titans a 10-0 lead. Outside linebacker Bud Dupree pressured Ryan on the play, and when he tried to get the ball to Parris Campbell, Adams stepped in front of the pass and took it the other way.
"I got a good break on it, and I was able to get my hand on it," Adams said. "And the rest is history."
Later in the quarter, the Titans made another play on defense when linebacker David Long Jr. stepped in front of another pass by Ryan and intercepted it at the Tennessee 38-yard line.
The Titans cashed that turnover into a 13-0 lead with a 28-yard field goal by Bullock with 1:57 left before halftime.
The Titans harassed Ryan throughout the first half, and they led 13-0 at halftime.
The Colts cut the lead to 13-7 late in the third quarter, however, on a four-yard touchdown pass from Ryan to Campbell, which capped a 12-play, 58-yard drive.
The Titans answered back with an 11-play, 55-yard drive that ended with another field goal by Bullock, this one from 38 yards, and Tennessee led 16-7.
Tannehill left the game briefly for the Titans with an ankle injury, replaced for one play by Malik Willis, but he returned to the contest after a quick trip to the team's injury tent.
After the Titans lost a fumble on a botched handoff from Tannehill to Willis, who went in motion, the Colts cut the lead to 16-10 on a 50-yard field goal by kicker Chase McLaughlin with 8:31 left.
But the Titans got a big kick from Bullock – from 48 yards – with 4:47 left to stretch the lead to 19-10.
When the Colts got the ball back, cornerback Terrance Mitchell forced a fumble that was recovered by safety Amani Hooker, and the Titans walked away with the win.
"We're just taking it one week at a time," Henry said. "We have to trust and believe in our culture and preparation in all three phases and focus on getting better and better every day. That's all we can do, week by week."
The Titans return to action next Sunday against the Texans in Houston.
The Tennessee Titans take on the Indianapolis Colts in Week 7 at Nissan Stadium.