The trip is a rare one for the Titans, who last played a regular season game at Candlestick Park on Oct. 3, 1999. That game was the team's first loss in a 13-win regular season. Since then, the Titans won the only other matchup, defeating the 49ers at LP Field on Nov. 27, 2005.
For the first time, Jeff Fisher and Mike Singletary will face each other on opposite sidelines as head coaches this week. The two were a part of the same 1981 Chicago Bears draft class and remained teammates through the Bears' 1985 Super Bowl Championship season. Singletary was named head coach of the 49ers midway through the 2008 season.
This Sunday's game will be televised regionally on CBS, including Nashville affiliate WTVF NewsChannel 5. Ian Eagle will handle play-by-play duties, while Rich Gannon will provide color commentary.
The Titans Radio Network, including Nashville flagship 103.3-WKDF, will broadcast the game across the Mid-South with the "Voice of the Titans" Mike Keith, color commentator Frank Wycheck, sideline reporter Cody Allison and gameday host Larry Stone.
LAST WEEK'S GAME
The Titans notched their first win of the season last week, taking down the division rival Jacksonville Jaguars 30-13 at LP Field.
Titans quarterback Vince Young started for the first time since September 2008 and completed 15 of 18 passes for 125 yards and one touchdown without an interception (114.1 rating).
But in the first game in NFL history that featured four rushing touchdowns of 50 or more yards, Jaguars running back Maurice Jones-Drew and Titans tailback Chris Johnson provided the biggest sparks. After Jones-Drew posted touchdowns of 80 and 79 yards, Johnson answered with scores of 52 and 89 yards.
Johnson set the franchise's all-time single-game rushing record with 228 yards on 24 carries, which tied his career high. His yardage total was the most by an NFL player in two years (296 by Adrian Peterson on Nov. 4, 2007) and tied for the 16th best total since the AFL-NFL merger in 1970. Johnson's effort helped the Titans finish with 305 rushing yards as a team, the second-highest total in franchise history (332 at Kansas City on Oct. 19, 2008).
Young completed a six-yard touchdown pass to Nate Washington, and Rob Bironas kicked three field goals to complete the Titans' scoring.
The 49ers were at Indianapolis last week. They took a 14-12 lead into the fourth quarter but were unable to halt Indianapolis' now-16-game winning streak, falling by a final score of 18-14. It was their third consecutive defeat after beginning the season 3-1.
Quarterback Alex Smith, the first overall draft pick in 2005, started for the first time this season, taking over for Shaun Hill. Smith was 19-of-32 for 198 yards, one touchdown and one interception against the Colts. His eight-yard touchdown pass to tight end Vernon Davis gave Davis seven touchdowns in the last five contests.