• The victory gave the Titans their second consecutive season with at least 10 wins. The last time they accomplished the feat was 2007 (10 wins) to 2008 (13).
• The Titans improved their record to 3-0 in primetime games in 2021.
• The Titans improved their all-time franchise record to 12-12 in Thursday games, including a 5-3 mark in Thursday primetime home games in the "Titans era" (since 1999).
• The Titans improved to 6-2 at Nissan Stadium in 2021, marking the eighth time since the stadium opened in 1999 that they registered at least six wins at home. The last time they did so was 2018 (6-2).
• Since Mike Vrabel became head coach of the Titans in 2018, the Titans are now are 13-4 against NFC teams. Their .765 interconference winning percentage is the third-best mark in the league behind only the Kansas City Chiefs (14-3; .824) and Baltimore Ravens (13-3; .813) in that time period.
• With offensive lineman Christian DiLauro appearing in his first game of the season, he became the 88th different player to participate in a game for the Titans in 2021. The total is the most in league history outside of the 1987 strike season that included replacement players.
• With Dillon Radunz making his first start at left tackle, he became the 52nd player this season to start at least once for the team. The Titans entered the week with the fourth-highest number of starters this season.
• The Titans won the turnover battle with two takeaways (two interceptions) and no giveaways. It was the eighth time in 2021 they had a positive turnover margin, and they improved to 7-1 in those contests.
• The Titans came back to win after trailing 10-0 in the third quarter. They joined the Baltimore Ravens (three games) and Pittsburgh Steelers (two) as the NFL's only teams in 2021 to have multiple double-digit, second-half comeback victories.
TEAM NOTES – OFFENSE
• The Titans converted a season-high nine third downs on 16 attempts. Their conversion rate of 56.3 percent was their second-highest percentage of the season (66.7 against Kansas City on Oct. 24). The Titans produced the most third-down conversions and the highest third-down percentage against the San Francisco defense in 2021.
• On eight attempts of third-and-10-plus, the Titans offense had six conversions (75.0 percent), tying the mark for the most such conversions in a game since the beginning of the 2000 season. It was the seventh occasion in that span that a team converted six times on third-and-10-plus and the first time since the Indianapolis Colts accomplished the feat (six conversions on nine attempts) against the Houston Texans on Sept. 30, 2018. In their first 14 games of the season, the Titans offense produced seven total conversions of 10-plus-yards on third down.
• The Titans offense scored touchdowns on both of the team's red-zone possessions, improving to 33-of-54 (61.1 percent) on the season.
• After being held scoreless in the first half, the Titans offense scored on four of its five possessions in the second half.
TEAM NOTES – DEFENSE
• The Titans improved upon what was the league's second-ranked rushing defense entering the contest. They went into Week 16 allowing opponents an average of 86.9 rushing yards per game, and against the 49ers they yielded 83 yards on 21 total attempts. The 49ers offense was averaging 126.6 rushing yards per game, which was the seventh-best average in the league.
• The Titans defense improved its streak to 10 games without allowing an individual 100-yard rushing performance by an opponent. The 49ers' leading rusher was Jeff Wilson Jr., who had 45 yards on 14 carries (3.2 avg.).
• Against the NFL's top red-zone offense entering the game (73.8 percent conversion rate), the Titans defense limited the 49ers to two touchdowns on four trips inside the 20.
DL DENICO AUTRY
• Recorded his third consecutive game with at least one sack, dropping Jimmy Garoppolo for a seven-yard loss on a third down in the second quarter. It marked the third three-game streak of his career with at least one sack.
• Improved his season total to eight sacks, which is the second-best total of his career behind only the nine sacks he had in 2018 as a member of the Indianapolis Colts. He increased his career total to 38.5 sacks.
• Totaled three tackles.
WR A.J. BROWN
• Returned to the lineup after missing three games on injured reserve and led the team with 11 receptions for 145 yards and a touchdown.
• His 11 receptions set a career high, eclipsing his previous high of 10 catches (twice, last at Indianapolis on Oct. 31, 2021).
• Produced the fifth-highest receiving yardage total of his career and his second-highest number of 2021.
• Recorded his 12th career 100-yard receiving game to become the only player for the franchise other than Bill Groman (16 games from 1960-61) and Charlie Hennigan (14 games from 1960-62) with at least 12 100-yard receiving games in his first three seasons. Brown went over the 100-yard mark against San Francisco on a 12-yard catch to convert a third-and-10 in the fourth quarter.
• His 18-yard touchdown reception in the fourth quarter was his team-leading fourth touchdown reception of 2021. He has 23 touchdown catches since entering the NFL in 2019, tied for eighth in the NFL.
• Recorded a 42-yard reception in the fourth quarter to convert a third-and-23.
• Caught eight passes on third down, six of which resulted in first downs. Since 1978, he became the first player to produce eight or more catches on third down in a game. Brown's six receptions for third-down conversions were the most in the NFL since Green Bay's Davante Adams had seven against Houston on Oct. 25, 2020.
K RANDY BULLOCK
• Connected on the game-winning, 44-yard field goal with four seconds remaining in the fourth quarter, breaking a 17-17 tie. It was his seventh career game-winning field goal and his third in his first season with the Titans (Sept. 19 at Seattle and Oct. 31 at Indianapolis).
• On a 38-yard field goal in the third quarter, he reached the 100-point mark on the season for the fourth time in his career. He has 106 points with two games remaining on the schedule.
S KEVIN BYARD
• Finished third on the defense with six tackles and added a forced fumble (out of bounds).
OLB BUD DUPREE
• Registered a sack in the fourth quarter, dropping Jimmy Garoppolo for a nine-yard loss. It was his third sack of 2021, increasing his career total to 42.5 sacks.
• Registered his second consecutive game with a sack since coming off injured reserve.
• Totaled four tackles.
ILB RASHAAN EVANS
• Tied for the team lead with seven tackles and added a forced fumble (recovered by the 49ers).
RB D'ONTA FOREMAN
• Totaled 17 yards and a touchdown on nine rushing attempts.
• Scored on a three-yard run in the third quarter. It was his second rushing touchdown of the season and the fourth of his career.
S AMANI HOOKER
• Registered his first interception of the season and the fifth interception of his career, picking off a Jimmy Garoppolo pass in 49ers territory in the third quarter and returning the ball 21 yards. The takeaway led to a Titans touchdown four plays later.
• Totaled five tackles.
CB JACKRABBIT JENKINS
• Registered his first interception in a Titans uniform and the 27th interception of his career. He helped prevent a 49ers touchdown by picking off a Jimmy Garoppolo pass in the end zone in the first quarter.
• With 27 interceptions since entering the NFL in 2012, he is tied with Stephon Gilmore for the fourth-highest total in the league during that time.
P BRETT KERN
• Appeared in his 195th career game with the Titans, which put him ahead of Brad Hopkins (194 games from 1993 to 2005) for third on the franchise's all-time games played list. Only Bruce Matthews (296) and Elvin Bethea (210) have more career games with the Titans/Oilers.
• Averaged 46.0 yards (39.6 net) on five punts with two punts placed inside the 20.
• Launched a 59-yard punt to pin the 49ers on their own five-yard line in the fourth quarter.
RB JEREMY McNICHOLS
• Led the team with 31 rushing yards on seven attempts, including two carries for 10 yards during the game-winning drive in the fourth quarter.
• Helped set up a third-quarter touchdown with consecutive rushing attempts of five yards and 10 yards.
OL DILLON RADUNZ
• Recorded his first career start. The second-round pick filled in at left tackle for injured starter Taylor Lewan.
WR CHESTER ROGERS
• Established a new career long with a 37-yard kickoff return in the first quarter. His previous long was a 30-yarder at New England on Nov. 28, 2021. He totaled 57 yards on two kickoff returns and also had a three-yard reception.
CB BUSTER SKRINE
• Tied for the team lead with seven tackles.
TE GEOFF SWAIM
• Totaled 10 yards on three receptions, including two catches for 10 yards on the game-winning drive in the fourth quarter. On the same drive, he also forced a defensive pass interference penalty for six yards and a first down.
QB RYAN TANNEHILL
• Completed 22 of 29 passes for 209 yards with one touchdown and no interceptions. He registered a passer rating of 106.8, earning his 45th career game with a passer rating of at least 100.0 and his 23rd such performance since joining the Titans in 2019.
• Added 22 rushing yards on three attempts, including a 23-yard scramble in the final two minutes of the fourth quarter to help set up the game-winning field goal.
• Credited with the 26th game-winning drive of his career, including a league-high 13 game-winning drives since joining the Titans in 2019.
• Recorded a 42-yard completion to A.J. Brown in the fourth quarter to convert a third-and-23, and four plays later, he found Brown for an 18-yard touchdown. It was his 15th touchdown pass of 2021 and his 193rd career touchdown pass.
• On third down, he was 11-of-13 (84.6 percent) for 149 yards with a passer rating of 114.4.
• Converted a career-high nine third downs on passing attempts. He previously had two career games in which he converted eight third downs on passing attempts, most recently against Detroit on Dec. 20, 2020.
• Extended his streak to 13 consecutive games with at least one passing or rushing touchdown.
• Recorded his 30th total win since joining the Titans in 2019, including 28 wins in the regular season and a pair of victories in the postseason.
WR NICK WESTBROOK-IKHINE
Totaled 38 yards on two receptions, including a 24-yard catch to convert a third-and-15 during a third-quarter scoring drive.